8454 El Paseo Grande La Jolla, CA, 92037

5 March, 1968

Dearest Linus,

Thank you for the material. The Daddy suggests that I get the Scott #2503 with the smoky-gray plastic cover which serves as a bit of protection with grand children about.

If you should want to bring your kids to La Jolla we have plenty of room. I can well understand you and their wanting to spend as much time as possible in Hawaii. We did sell all of our cattle except some young ones. We did this because of our decision to come to La Jolla this year.

I do not know what the Daddy told you about my illness but I think he was more frightened than the situation justified. At least they were able to find nothing wrong and my recovery was very rapid. At any rate, I seem perfectly all right now except for being a bit unhappy here in La Jolla. We’ve just had a week at UCLA and have his (the Daddy’s birthday) at Linda’s. Crellie and Lucy came and Stan Schaefer flew down with the Festschrift – a loved volume bound in leather for the presentation copy and the Daddy was completely surprised and happy too. He is sending a copy to you. It is a good book and Stan is proud of it.

You are to have a birthday soon and I send you much love.

You should come here and I would make you a cake.

Hugs and kisses,

AP

I enclose a check.

March 5, 1968

Dr. Peter Pauling

Chemistry Department

University College London

Gower Street WC1

London, England

Dear Peter:

Thanks for your letter, which has reached me only shortly after my birthday. I am glad to have your birthday wishes, and especially glad to see your fine article in the Festschrift. Thanks very much for it. I hope that your work along these lines goes along very well.

I think that the Festschrift is wonderful—-about the best Festschrift that I have ever seen.

Linda and Barclay had a nice birthday party for me: wonderful steak. Mama and I were at UCLA all week, from Sunday to Saturday, except for the evening in Pasadena. Stanley Schaefer came down from San Francisco, bringing the specially bound copy of the Festschrift for presentation to me at the birthday party. Lucy and Crellin were there, also. I gave three lectures on molecular biology at UCLA, and visited all of the departments associated with the Molecular Biology Institute. Mama and I took part in a two-hour panel discussion of social aspects of molecular biology, with members and students in some of the departments, and we also had a joint meeting with students in the student houses one evening. On Saturday we went to UC Irvine, and on Sunday evening I gave a lecture there. Now we are back home, in La Jolla.

By the way, there is a University of San Diego (San Diego State University) , and your letter was sent there. I am in the University of California, San Diego, which is in La Jolla, 92037. A good address is just P. 0. Box 109, La Jolla, California 92037.

I am pleased that you are satisfied with the silver cobalticyanide paper. The mistake that you point out in Figure 2 was not present on the original. I shall ask Mrs. Junkermann to be sure to remind me to remove the comma between College and London.

I have ordered a couple of copies of Jim's book, but they have not yet arrived. I shall send you one when they do arrive.

Much love from,

Daddy

7 March 1968

Dear Daddy,

I now regret that I did not send you a telegram for your birthday and apologize for not doing so. I was very busy at the time and felt I could not go to the post office and send it (I do not have a telephone.)

I need a little advice and ask you for it. I have been reading a book published last year entitled "Drugs Affecting the Peripheral Nervous System" edited by Alfred Burger and written by leaders in the field that is full of structure-activity relationships that are out of date in terms of my festschrift chapter. I could write a couple of papers for PNAS and ask you to send them in now. One perhaps would be the best available distances between the reactive groups of the active molecules and the other would be a speculative article on the four possible forms of acetylcholine that may be active. The four forms are that shown in the festschrift and that proposed by Culvenor and Ham (see festschrift) and their mirror images. These have been calculated by Liquori on van der Waals alone to be equally energetic (JMB, in the press or soon; I refereed it). The advice I need is should I proceed now when very little real information is available or should I wait until I have done some more structures and have more real information?

The point about the four forms is that there are several cell-cell communication systems that use acetylcholine as mediator but each system is different to the others as determined by the effects of other molecules. I hope to be able to separate these systems structurally in terms of the structures of these other molecules. At the moment all I can do is speculate. The first paper, however, would clear up a number of what I consider to be structural mistakes that are reproduced in this book. The papers would not be chemistry but rather physiology or pharmacology.

I hope you and mamma are well. What was the result of the vitamin C experiment and schizophrenics?

Much love,

Peter

March 8, 1968

Miss Elise Jerard 115

Central Park West New York

City 10023

Dear Miss Jerard:

Your letter to me is like a number of others that I have received from antagonists of the fluoridation of water, in its emotional and pejorative language.

I believe that I have made a good decision about the matter of fluoridation of domestic water supplies. I have examined the evidence available to me, and have reached the same decision that my friend Professor Theorell reached, through the same process.

I have taken a public stand on fluoridation of water supplies for many years, and my support of fluoridation was discussed in the New York Times and elsewhere, during the last ten years. My stand was taken long before I was elected Honorary President of the International Society for Research on Nutrition and Vital Substances. It is insulting of you to criticize me for having accepted the invitation to me to be Honorary President of this Society.

I must say that the fact that you are willing to make this insulting statement fits in with the pattern of your writing generally. Many of your statements are lacking in a rational or logical basis. For example, you mention that some anesthetics contain fluorine. The presence of fluorine in anesthetics has nothing to do with the fluoridation of water supplies. These anesthetic agents are stable against hydrolysis and other attack in the human body, and do not liberate any fluoride ion.

Also, in your letter there is a suggestion of contrast between "natural fluorides" and "artificial fluoridation". This contrast does not have any rational basis. I believe that I have made this point to you in an earlier letter.

I suggest that you take enough time to study the scientific basis of the arguments that you present, and then reject those that do not have any scientific basis.

Sincerely,

Linus Pauling

LP:jj

March 11, 1968

Professor Carroll Richardson

865 Canyon View Drive

Laguna Beach, California 92651

Dear Carroll:

I was pleased to see you at Irvine, and also pleased now to receive your fine letter and the copy of the notice that you sent out.

We are going through a terrible time now, and I hope that the future will become brighter.

Cordially,

Linus Pauling

LP:jj

March 13, 1968

Mrs. Anita Oser Pauling

Aroda

122 Vesenaz Geneva,

Switzerland

Dear Anita:

I hope that you and the children are all in good shape. Ava Helen and I were very pleased that we could see you when we were in Geneva.

We have been enjoying ourselves in La Jolla. I like being professor of chemistry in the University of California, San Diego, and being able to carry on my scientific and medical work. I think that Mama was happier in Santa Barbara than here in La Jolla, but that she feels that we should be in the place where my work goes along best.

You no doubt remember that for the last ten or twelve years, except very recently, I had some work going on the molecular basis of mental disease, especially mental retardation, with support of a grant from the Ford Foundation, a grant from the National Institutes of Health, and to some extent from your gift to the California Institute of Technology. I have continued to think about this problem, and during the last two years I formulated some rather original ideas about schizophrenia and other forms of mental illness. These ideas are described in a paper entitled Orthomolecular Psychiatry, a copy of which is enclosed. I have just read proof on this paper, which will appear in the journal Science in about one month.

Also, I have been doing some experimental work, as described in the accompanying research report.

After some uncertainty Mama and I have decided that we should stay at La Jolla for perhaps three years more, in order that I could continue with my scientific work, especially the attack on schizophrenia. We have made arrangements with the University Hospital of San Diego and are in the process of making arrangements with two other local hospitals for access to mental patients and cooperation with the medical staffs.

A complication arose in connection with my continuation here, in that two weeks ago I reached the age sixty seven, which is the retirement age for the University of California. Many people are appointed to continue research after retirement, and arrangements to do this for me are moving along, although rather slowly. Because of this complication it has not been possible for me to apply to National Science Foundation or National Institutes of Health for a grant for support of my work. I am, by the way, planning a research program to be carried out during this period of three years at the cost of about $100,000 per year, and I have four people already under appointment for the coming year.

Is there the possibility that you could make a gift for support of some of my work during the coming year or the coming three years? I think that the most convenient way, if you wish to make a gift, is to make it to the Fund for the Republic. I am still a member of the staff at the Center for the Study of Democratic Institutions, which is operated by the Fund for the Republic, and am on leave at present. It has turned out that it is easier to administer grants through the Fund for the Republic, which is tax-exempt, than through the University of California, which has some special regulations.

I should also mention that the war in Vietnam has caused a decrease in the budgets of the National Science Foundation and the National Institutes of Health, making it less likely than formerly that favorable action would be taken on a new application.

Much love from,

Daddy

P.S. Under separate cover I am sending you a copy of the book Structural Chemistry and Molecular Biology. This book was presented to me on my sixty seventh birthday by the president of W. H. Freeman and Company. It is a Festschrift, prepared by former students and associates of mine. I think that it is a wonderful book, and I hope that you like it, too.

Daddy

March 19, 1968

Miss Edith Mark

Chapel Library Center

1580 Chapel Street

New Haven, Conn.

Dear Edith:

I am pleased that you should write to me, to ask what my favorite book was when I was young.

I read many books when I was a small boy. The one that I remember best, which I read first when I was eight years old and then many times during the next few years, is Through the Looking Glass, by Lewis Carroll. I still remember many of the verses in it. I did not have a copy of his other book, Alice in Wonderland, and I read it only some years later.

Sincerely yours,

Linus Pauling

LP:jj

March 27, 1968

TO: Drs. Galzigna and Robinson

FROM: Linus Pauling

SUBJECT: Loading Tests of Vital Substances

Dr. Galzigna in his memorandum of 25 March 1968 suggested that some studies be made of the rate of absorption of a vitamin by the brain and the rate of elimination with urine, as well as of rates of transmission through the blood-brain barrier.

I suggest that you two discuss with one another the details of experiments that might be carried out along these lines, so that we can make plans for the future.

I was impressed by the results reported by Roger J. Williams on variations from individual to individual guinea pigs in requirements for ascorbic acid. It may be that a worthwhile investigation would be the study of ascorbic acid in guinea pigs, to see whether the ratio of concentration in the cerebral spinal fluid to that in the blood shows similar variation, both under steady-state conditions and after injection of a large dose. I doubt that we should plan to work with animals larger than guinea pigs, during the coming year, and we would have to look at the matter of use of an animal room, if we do any animal work.

Another comment in the memorandum by Dr. Galzigna of 25 March 1968 is that we should investigate the matter of the pink spot and similar controversial tests. I suggest that you go through the literature on the pink spot and on the Hoffer-Osmond mauve factor, and make a proposal about steps that we might take in this direction.

Linus Pauling