March 7, 1968 - Linus Pauling Day-by-Day

Check, from AHP to Pearl Lang: $35.00. [Filed under LP Biographical: Business and Financial Assorted Bills, Receipts and Invoices, 1965-1968, Box # 4.062, Folder # 62.2, Receipts, 1967-1968.]

Letter from Dr. Edward Rubenstein to LP, RE: Gives an update on his and his colleagues current work on the placental induction of fetal hemoglobin synthesis. Writes about using a human bone marrow system incubated with human placental homogenate. [Filed under LP Correspondence: Box# 343, Folder# 343.5]

Letter from Hugh Moore to LP, RE: Asks for LP to approve and return an enclosed statement showing support for the Campaign to Check the Population Explosion which urges the United States Government to inaugurate a crash program. [Filed under LP Correspondence: Box# 315, Folder# 315.5]

Letter from LP to Dr. Jerome Davis, RE: LP writes that he is sorry to learn that the Center has not shown interest in Davis' proposal. He adds that he cannot work on a study due to other commitments. [Filed under LP Correspondence: Box# 100, Folder# 100.2]

Letter from LP to Mr. S. K. Vidyarthi, RE: Writes about the problem of the instability of planar quadricovalent tripositive copper and the calculation of values of enthalpy for different structures. [Letter from S. K. Vidyarthi to LP 6, 1968] [Filed under LP Correspondence: Box 427, Folder 427.28]

Letter from LP to Professor A. Rachman, RE: Writes that he has been spending the year at the University of California at San Diego as a Professor of Chemistry. Sends the only new paper he has published on nuclear structure. [Filed under LP Correspondence: Box# 326, Folder# 326.2]

Letter from LP to Professor Alfred Stern, RE: Asks if Professor Stern and Gloria could visit La Jolla on the weekend of March 29^th. [Filed under LP Correspondence: Box# 368, Folder# 368.1]

Letter from LP to Professor E. Bright Wilson, Jr., Department of Chemistry, Harvard University, RE: Writes that he plans on going over the remaining chapters of the book and will send comments as with the first chapter. LP hopes this book will help to answer questions about quantum mechanics that have been troubling him. Thanks Bright for the volume Structural Chemistry and Molecular Biology. [Letter from E. Bright Wilson, Jr., Department of Chemistry, Harvard University, to LP 3, 1968] [Filed under LP Correspondence: Box 438, Folder 438.5]

Letter from LP to Professor Jurg Waser, Gates and Crellin Laboratories, California Institute of Technology, RE: Writes that he is not planning on coming to Pasadena on Monday, May 6, but is planning on being there Thursday, May 9, and asks if that is acceptable. Also asks what Professor Waser would like him to talk about to the freshman. [Letter from Jurg Waser, California Institute of Technology, to LP 0, 1968] [Letter from Jurg Waser, California Institute of Technology, to LP 2, 1968] [Filed under LP Correspondence: Box 431, Folder 431.8]

Letter from LP to Professor Stanley Backer, RE: Sends a thank you letter and notes that he feels awarding Professor Herman F. Mark the Nobel Prize in Chemistry would be justified. [Filed under LP Correspondence: Box# 42, Folder# 42.2]

Letter from Peter Pauling to LP. [Filed under LP Biographical: Personal & Family, Family Correspondence: Peter Jeffress Pauling, 1960-1974. Box # 5.044, Folder # 44.10, Correspondence: Peter Pauling, 1968.]

7 March 1968

Dear Daddy,

I now regret that I did not send you a telegram for your birthday and apologize for not doing so. I was very busy at the time and felt I could not go to the post office and send it (I do not have a telephone.)

I need a little advice and ask you for it. I have been reading a book published last year entitled "Drugs Affecting the Peripheral Nervous System" edited by Alfred Burger and written by leaders in the field that is full of structure-activity relationships that are out of date in terms of my festschrift chapter. I could write a couple of papers for PNAS and ask you to send them in now. One perhaps would be the best available distances between the reactive groups of the active molecules and the other would be a speculative article on the four possible forms of acetylcholine that may be active. The four forms are that shown in the festschrift and that proposed by Culvenor and Ham (see festschrift) and their mirror images. These have been calculated by Liquori on van der Waals alone to be equally energetic (JMB, in the press or soon; I refereed it). The advice I need is should I proceed now when very little real information is available or should I wait until I have done some more structures and have more real information?

The point about the four forms is that there are several cell-cell communication systems that use acetylcholine as mediator but each system is different to the others as determined by the effects of other molecules. I hope to be able to separate these systems structurally in terms of the structures of these other molecules. At the moment all I can do is speculate. The first paper, however, would clear up a number of what I consider to be structural mistakes that are reproduced in this book. The papers would not be chemistry but rather physiology or pharmacology.

I hope you and mamma are well. What was the result of the vitamin C experiment and schizophrenics?

Much love,

Peter

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