Activity Listings
- [?] journal entry in journal entitled "France and England 1952 also Toronto" RE: [drawings of molecular compounds] "Adenine. Guanine, Uracil, Bytosine. Alkali. 8 nucleotides = 4 pairs isomers (2 and 3 phosph.). a b.
Enzmes. 5- phosphates of all 4 nucleosides + b - phosphates of [pyrim?]. nucleosides."
- LP journal entry in journal entitled "France and England 1952 also Toronto" RE:
"1. Letter to Nature on compound helixes and hair, horn, etc. P and C.
2. PNAS [Proceedings of the National Academy of Sciences] description and coordinates of compound helices. P and C.
3. PNAS. Detailed discussion of hair and horn. P, C, others.
Call AB[6?] the [alpha] cable?
Get someone to put hair in solution and fractionate it.
Also porcupine quill.
Also feather rachis.
Get someone to try to make a preparation of bacterial flagella.
How about sperm tails?
Nucleic acid- try to predict a structure.
Lignin- try to predict a structure.
Check the x-ray data for actin and myosin and actomyosin. Perhaps myosin is pure AB[6?], actin pure C."
- LP journal entry in journal entitled "France and England 1952 also Toronto" RE: "Proteins. I think that the [alpha] helix might bend by a sequence [alpha] - cis - trans - cis - [alpha]" [drawing of this below].
"Todd. Two p. Adenine. Quanine. Cytosine. Uracyl? [Uracil] These four and D- ribofuranose give nucleosides; with phosphoric acid give nucleotides; the four in some sequence give ribonucleic acid. Deoxyribonucleic acid has Deoxy D- ribofuranose. Also a fifth purine or pyrimidine that Todd discovered. All possible dinucleotides have been isolated."
"Wilkins and bSeeds. Faraday [Soc.] [about] 1950 showed calf thymus NP and oriented NA to have same plane of purine and pyrimidine res."
"Ambrose and Butler IR dichroism of stretched nucleoprotein show plane of planes of purine and pyrimidine rings are normal to direction of stretching of nucleoprotein films. Also position of CO protein-band shows [Beta] stretched chains along stretching axis."
"My lecture. Def. [definition] of monomer. Simple chains (held by cov.[covalent] bonds. Shape. single chain gives molecule with no symmetry) if they retain configuration essentially when separated; but if there are several so intertangled that configuration is lost the aggregate is the monomer. Some arbitrariness as in my definition of chem. bond, which has been criticized. Nature of Forces. + -, H- bond, v.d.w. Complementariness.
Stickiness of proteins- See single sheet.
Denaturation- many kinds.
Careful change producing associating molecules. For 1 symmetry AandA- lead to helix cases: steric hindrance may stop produce at P2, P3, P4... 5 [degrees] bending may portrait ring (with some strain)."
[drawing to the left].
[drawings of four different helix and chain type structures above].
[in reference to first drawing] "open helix- may give nematic liquid Xls."
[in reference to second drawing] "May easily Xlize."
[in reference to third drawing] "Pitch may equal molec? diameter; giving tube with extra [unidentified word] stabilization."
[in reference to fourth drawing] "Pitch = 2 x molec. diam. Two interpenetrating chains."
"Dimetric" [drawing to right]
"Leeway of 5 [degrees] might permit second layer or also a third, if diameter is large, giving tube with thicker wall. [drawing of helix? below]. Large helix with five [degrees] leeway could stretch perhaps 100%. [two drawings below]. KH Meyer 1929 (Meyer and Mark). Change way he by splitting off AA res. (ovalb [to] plakalb fibrinogen [to] fibrin) or addition or subtraction of O2 or other small molec. or change in configuration."
"Relation [unidentified word] inner and outer might cause bend. In general this would give a larger helix. Perhaps triple chain flagellae are 3 such. [small illustration to the right]. H.R. Crane."
"Fraser. Octopus sperm heads can be oriented by smearing, show IR dichroismas in nucleic acid oriented. But F says freq. of NH suggests [alpha] helices, at rt. angles [drawing] to stretching axis, although he prefers [beta] [unidentified symbol] to axis."
"Edsall says fibrin forms fibers 100 A to 1000 A or more in diameter. The show striations with period 250 A (Hall says 230 [plus or minus] 30A- some variation). Just 1/3 length of fibrinogen molecule. Our (Rudall) 118 [Angstroms] repeat = 1/2 this period."
"1. Make some H bonds (rods) with [plus or minus] 0.1 [Angstoms] extensiblility and compressibility [four drawings below] Aluminum bent to this shape?"
- LP journal entry in journal entitled "France and England 1952 also Toronto" RE: Visited Ac.d. Sciences. Prince de Broghe- Prof. Lacassagne drove me home.
- Letter from Carl Niemann to Dr. N. Uri of the U. of Chicago RE: responds to Dr. Uri for LP in his absence. Says that they are glad to have him visit Caltech and give a seminar in the division of Chemistry and Chemical Engineering. [related letter from LP to Dr. Uri July 21, 1952] [Filed under LP Correspondence: Box #421, Folder #11].
- Letter from Dr. Carl Niemann to Dr. S. M. McElvain RE: writes this letter in LP's absence in regard to the proposed visit of Professor Karl Ziegler. Writes that they would be glad to have him in the Division of Chemistry and Chemical Engineering during his western tour in October. Goes on to discuss the financial details of the visit. [Filed under M: Correspondence 1952, Box #256, Folder #3]
- [?] journal entry in journal entitled "France and England 1952 also Toronto" RE: [drawings of more molecular compounds] LP journal entry in journal entitled "France and England 1952 also Toronto" RE: "Always 3-ORO-5. Jeffrey says Parry at Leeds has done CS of uracil thiouracil barbituric acid."
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August
4, 1952
