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Ewan Cameron Papers, 1935-1997

1. Mice Cancer Experiments. 1970-1997.

These materials document a set of mice experiments that Cameron carried out in collaboration with Dr. Jeff Bland and Dr. Richard Marcuson that explored the effects of dietary fatty acids on incidences of breast and colon cancers. The serie includes a wide range of records, from experiment proposals and descriptions, to budgets, data sheets, correspondence, manuscripts and related articles. The boxes are arranged according to the stage of a given experiment, with files organized by date, as applicable.


10 boxes

Boxes 1.001 - 1.010 (Page: 1 - 10)



1.001.
Mice Cancer Experiments: Administrative Records and Data Analysis. 1973, 1983-1988.
1.1.
Notes: "Proposed New Animal Study - Preliminary Planning Meeting". November 28, 1983.
1.2.
Mice Cancer Experiment description. undated.
1.3.
Mice Cancer Study I: Protocol. May 3, 1984.
1.4.
Mouse Study II: Protocol. undated.
1.5.
Mouse Study III: Protocol. undated.
1.6.
Cameron Notes re: Mouse Cancer Study. undated.
1.7.
Materials re: Mouse Cancer Study diets. Summer 1985 - April 1986.
1.8.
Materials re: Mouse Cancer Experiment budget. February 24 - September 6, 1988.
1.9.
Receipts: Mice Cancer Experiments expenditures. 1984, 1987.
1.10.
Calendars: Mice Cancer Experiment schedules. 1984-1985, 1988.
1.11.
Notes: Efamol Study Randomization Schedule. January 5, 1984.
1.12.
Notes: Efamol Study Palpation Schedule. 1984.
1.13.
Mice Cancer Experiments: Set-up for Chart. undated.
1.14.
LPI Semi-annual Progress Report: Mouse Mammary Tumor Project. July 1984.
1.15.
Mice Cancer Experiments: preliminary data analysis. March 1, 1985.
1.16.
Graphs re: Fats/Mouse Mammary Tumor Study. 1985-1986.
1.17.
Mice Cancer Experiments: visuals. 1985.
1.18.
Mouse Cancer Study I: graphs and figures. 1985-1986.
1.19.
Mouse Cancer Study II: Colon Cancer. 1986-1987.
1.20.
Mouse Cancer Study II: n-6 Fatty Acids/n-3 Fatty Acids. undated.
1.21.
Mouse Cancer Study: literature review. 1973, 1985.
1.22.
Notes: "Conversion of the Essential Fatty Acid, Linoleic Acid, to Prostaglandins". undated.
1.23.
Notes: "Wilcoxin Test on Maximum Number of Tumors". March 1, 1985.

1.002.
Mice Cancer Experiments: Raw Data and Printouts. 1984-1987, 1990.
2.1.
Mice Cancer Experiments: cancer growth rate data. 1984, 1986.
2.2.
Mice Cancer Experiments: "Survival Analysis on Time to First Tumor". 1985-1986.
2.3.
Mice Cancer Experiments: Data from "Fat 89 - Body Weights". January 28, 1990.
2.4.
Mice Cancer Experiments: Data from "Fat 89 - Food Consumption". February 16, 1990.
2.5.
Mice Cancer Experiments: "Tumor Incidence By Group and Week". May 1986.
2.6.
Mice Cancer Experiments: Assorted Printouts. November 16, 1987.
2.7.
Mice Cancer Experiments: "Frequency Distribution of the Maximum Number of Tumors on Each Mouse Over Time". September 28, 1984.
2.8.
Mice Cancer Experiments: "Number of Tumors per Animal in Each Group". undated.
2.9.
Mice Cancer Experiments: "Recent Body Weight and Food Consumption Statistics". 1984-1986.
2.10.
Mice Cancer Experiments: animal condition charts. undated.
2.11.
Mice Cancer Experiments: Assorted Charts. October 1985 - April 1986.
2.12.
Mice Cancer Experiments: Mice Weight Data. 1984.
2.13.
Mice Cancer Experiments: Mice Tumor Data, part 1. 1984.
2.14.
Mice Cancer Experiments: Mice Tumor Data, part 2. 1984-1985.

1.003.
Mice Cancer Experiments: Animal Necropsy Records. August 1984 - March 1985.
3.1.
Mice Cancer Experiments: Animal Necropsy Records. August 1984.
3.2.
Mice Cancer Experiments: Animal Necropsy Records. September 1984.
3.3.
Mice Cancer Experiments: Animal Necropsy Records, part 1. January 1985.
3.4.
Mice Cancer Experiments: Animal Necropsy Records, part 2. January 1985.
3.5.
Mice Cancer Experiments: Animal Necropsy Records. February 1985.
3.6.
Mice Cancer Experiments: Animal Necropsy Records. March 1985.

1.004.
Mice Cancer Experiments: Final Data from Study I. July - August 1984.
4.1.
Mice Cancer Data: Group 1. July 1984.
4.2.
Mice Cancer Data: Group 2. July 1984.
4.3.
Mice Cancer Data: Group 3. July 29, 1984.
4.4.
Mice Cancer Data: Group 4. July, 30 1984.
4.5.
Mice Cancer Data: Group 5. July 31, 1984.
4.6.
Mice Cancer Data: Group 6. July 31, 1984.
4.7.
Mice Cancer Data: Group 7. August 1, 1984.
4.8.
Mice Cancer Data: Group 8. August 1, 1984.
4.9.
Mice Cancer Data: Group 9. August 2, 1984.
4.10.
Mice Cancer Data: Group 10. August 3, 1984.
4.11.
Mice Cancer Data: Group 11. August 5, 1984.
4.12.
Mice Cancer Data: Group 12. August 6, 1984.
4.13.
Mice Cancer Data: Group 14. August 6, 1984.
4.14.
Mice Cancer Data: Group 15. August 7, 1984.
4.15.
Mice Cancer Data: Group 16. August 7, 1984.
4.16.
Mice Cancer Data: Group 17. July 5, 1984.

1.005.
Mice Cancer Experiments: Richard Marcuson Memoranda. 1984-1985, 1988.
5.1.
Marcuson Memorandum re: Cancer Morbidity. July 13, 1984.
5.2.
Marcuson Memorandum re: Efamol Study Feeding Design. July 13, 1984.
5.3.
Marcuson Memorandum re: Cancer Growth Rates. July 17, 1984.
5.4.
Marcuson Memorandum re: Cancer Morbidity. July 27, 1984.
5.5.
Marcuson Memorandum re: Food Consumption. August 16, 1984.
5.6.
Marcuson Memorandum re: Control Groups. August 30, 1984.
5.7.
Marcuson Memorandum re: Pairwise Significance Tests. September 6, 1984.
5.8.
Marcuson Memorandum re: Study Start-up. September 7, 1984.
5.9.
Marcuson Memorandum re: Vitamin C Dose Response. September 13, 1984.
5.10.
Marcuson Memorandum re: Statistical Methods Series. September 17, 1984.
5.11.
Marcuson Memorandum re: Effects of Vitamin C Administered After Tumor Detection. September 20, 1984.
5.12.
Marcuson Memorandum re: Restriction of Food Consumption. September 24, 1984.
5.13.
Marcuson Memorandum re: Comparison of Se Diet with Ad Lib Control Diet. September 27, 1984.
5.14.
Marcuson Memorandum re: Comparison of Vitamin A Diet with Ad Lib Control Diet. October 4, 1984.
5.15.
Marcuson Memorandum re: Cancer Morbidity. October 8, 1984.
5.16.
Marcuson Memorandum re: Restriction of Food Consumption. October 8, 1984.
5.17.
Marcuson Memorandum re: Cancer Morbidity. October 16, 1984.
5.18.
Marcuson Memorandum re: Food Restriction. October 19, 1984.
5.19.
Marcuson Memorandum re: Cancer Morbidity and Growth. October 30, 1984.
5.20.
Marcuson Memorandum re: Cancer Morbidity. December 18, 1984.
5.21.
Marcuson Memorandum re: Cancer Morbidity. December 27, 1984.
5.22.
Marcuson Memorandum re: Cancer Morbidity. February 6, 1985.
5.23.
Marcuson Memorandum re: Survival Curves. February 28, 1985.
5.24.
Marcuson Memorandum re: Cancer Growth Rate. March 1, 1985.
5.25.
Marcuson Memorandum re: Tumor Multiplicities. March 7, 1985.
5.26.
Marcuson Memorandum re: Tumor Yields. August 17, 1988.

1.006.
Mice Cancer Experiments: Manuscripts and Drafts. 1987, 1989.
6.1.
Manuscript: "Divergent Effects of Omega-6 and Omega-3 Fatty Acids on Induced Breast Cancer in Mice". undated.
6.2.
Manuscript: "Divergent Effects of Omega-6 and Omega-3 Fatty Acids on Mammary Tumor Development in C3H/Heston Mice Treated with DMBA". 1987, 1989.
6.3.
Manuscript: "The Effect of Some Different Dietary Fatty Acids Upon Induced Breast Cancer in Mice". undated.
6.4.
Manuscript: "Essential Fatty Acids and Induced Breast Cancer in Mice". undated.
6.5.
Manuscript: "The Influence of Various Dietary Fatty Acids Upon Induced Breast Cancer in Mice". undated.

1.007.
Mice Cancer Experiments: Correspondence. 1980, 1985-1988.
7.1.
Correspondence: Jeffrey Bland. 1987-1988.
7.2.
Correspondence: J.F. Carter. July 29, 1987.
7.3.
Correspondence: Desmond Davies, [R.P. Scherer Co.]. 1986-1987.
7.4.
Correspondence: R.P. Scherer Corporation. 1986-1988.
7.5.
Correspondence: John W. Farquar. 1987-1988.
7.6.
General Correspondence re: mice cancer experiments. undated.
7.7.
Correspondence: Mira Goetsch. undated.
7.8.
Correspondence: Stephen Maddox. 1986, 1988.
7.9.
Correspondence: Ralston-Purina. 1985, 1987.
7.10.
Correspondence: resident statistician. undated.
7.11.
Correspondence: R.D. Rice [Marfleet Refining Co. Ltd.]. October 14, 1980.
7.12.
Correspondence: John L. Stegmaier. 1987.
7.13.
Correspondence: Paul Stitt [Natural Ovens of Manitowok]. August 4, 1987.

1.008.
Mice Cancer Experiments: Efamol, Prostaglandins and Other Studies. 1979-1986.
8.1.
Correspondence re: Efamol. 1979, 1981, 1983.
8.2.
Assorted Materials re: Efamol. undated.
8.3.
Lung Cancer Regime. undated.
8.4.
Prostaglandins. 1979-1982.
8.5.
Prostaglandins and Immunity. April 1980.
8.6.
Prostaglandin E1 Therapy of Murine Chronic Serum Sickness. 1980.
8.7.
Treatment of Sjorgen's Syndrome. undated.
8.8.
Efamol Clinical Trials in Cancer. 1980, 1982-1986.

1.009.
Mice Cancer Experiments: David Horrobin and Efamol Research Institute matierials. 1979-1981, 1986-1987.
9.1.
Correspondence: David Horrobin and Efamol Research Institute. 1980, 1986-1987.
9.2.
Notes: David Horrobin and Efamol Research Institute. 1981.
9.3.
Papers/Studies: David Horrobin and Efamol Research Institute. 1979-1981.
9.4.
Articles re: David Horrobin and Efamol Research Institute. undated.

1.010.
Articles Related to Mice Cancer Experiments. 1970-1988, 1997.
10.1.
Abraham, S. et al. "Lipids and Lipogenesis in a Murine Mammary Neoplastic System", Control Mechanisms in Cancer, 1976.
10.2.
Adler, S. et al. "Hemopoiesis in Mice Treated with Phenylhydrazine or Phenlyhydrazine + Endotoxin Administered by Continuous Infusion". 1982.
10.3.
Bland, Jeffrey. "Serum Lipids, Prostaglandins, and Marine Oils", Journal of IAPM, 1983.
10.4.
Booyens, J. "Essential Fatty Acid Metabolism and Metabolites", SA Medical Journal, 64, November 19, 1983.
10.5.
Booyens, J. "Polyunsaturated and Essential Fatty Acids", SA Mediese Tydskrif, 64, August 6, 1983.
10.6.
Chaintreuil, J. et al. "Effects of Dietary -Linolenate Supplementation on Serum Lipids and Platelet Function in Insulin-Dependent Diabetic Patients", Human Nutrition: Clinical Nutrition, 38C:121-130, 1984.
10.7.
Clinton, Steven et al. "The Combined Effects of Dietary Protein and Fat on 7,12-Dimethylbenz(a)anthracene-Induced Breast Cancer in Rats", American Institute of Nutrition, 1984.
10.8.
Cohen, L.A. et al. "Influence of Dietary Medium-Chain Triglycerides on the Development of N-Methylnitrosourea-induced Rat Mammary Tumors", Cancer Research, 44:5023-5028, November 1984.
10.9.
Cramer, Daniel et al. "Dietary Animal Fat in Relation to Ovarian Cancer Risk", Obstetrics and Gynecology, 63, 6, June 1984.
10.10.
Dunbar, L. et al. "Enzyme Deletions and Essential Fatty Acid Metabolism in Cultured Cells", The Journal of Biological Chemistry, 250, 3, February 10, 1975.
10.11.
Everett, Raymond. "Factors Affecting Spontaneous Tumor Incidence Rates in Mice: A Literature Review", CRC Critical Reviews in Toxicology, 13, 3, 1984.
10.12.
Fish Oil Articles. undated.
10.13.
Galland, Leo. "The Chemistry of Healing: Fatty Acids and the Cell Code", Gesell Institute of Human Development Update, 3, 3, Spring 1984.
10.14.
Harman, John. "Chronic Glomerulonephritis and the Nephrotic Syndrome Induced in Rats with N,N'-Diacetylbenzidine", Journal of Pathology, 104, 1971.
10.15.
Hirono, Iwao et al. "Carcinogenicity Test of Shikimic Acid in Rats", Toxicology Letters, 1:9-10, 1997.
10.16.
Hoffsten, Phillip. "Studies of Albuminuria and Proteinuria in Normal Mice and Mice with Immune Complex Glomerulonephritis", Journal of Laboratory and Clinical Medicine, 86, 6, 1975.
10.17.
Horvath, Paula. "Synergistic Effect of Vitamin E and Selenium in the Chemoprevention of Mammary Carcinogenesis in Rats", Cancer Research, 43:5335-5341, November 1983.
10.18.
Jain, Sushil. "The Accumulation of Malonyldialdehyde, a Product of Fatty Acid Peroxidation, Can Disturb Aminophospholipid Organization in the Membrane Bilayer of Human Erythrocytes", Journal of Biological Chemistry, March 25, 1984.
10.19.
Jariwalla, Raxit et al. "Effects of Dietary Phytic Acid (Phytate) on the Incidence and Growth Rate of Tumors Promoted in Fischer Rats by a Magnesium Supplement", Nutrition Research, 8:813-827, 1988.
10.20.
Kendler, Barry. "Gamma-Linolenic Acid: Physiological Effects and Potential Medical Application", Journal of Applied Nutrition, 39, 2, 1987.
10.21.
Knock, F. et al. "Selected Sulfhydryl Inhibitors Capable of Inducing Immunity Against Cancer in Mice", Oncology, 36:197-201, 1979.
10.22.
Lancet Correspondence: Durrington, Paul "HDL Cholesterol in Diabetes Mellitus," July 22, 1978.
10.23.
Lancet Correspondence: Weiner, Michael "Cholesterol in Foods Rich in Omega-3 Fatty Acids"; Simopoulos, Artemis, and Norman Salem, Jr.: "Purslane: A Terrestrial Source of Omega-3 Fatty Acids," September 28, 1986.
10.24.
McCormick, David et al. "The Inhibition of Rat Mammary Tumors by Dietary Retinyl Acetate at Various Times During and After Treatment with a Carcinogen", AACR Abstracts, 1979.
10.25.
Moore, T.C. et al. "Increased Concentrations of Prostaglandin E2 in Lymph Efferent from Tumours", IRCS Medical Science, 10, 345, 1982.
10.26.
Nishii, Yasuho et al. "Osseous Changes and Abnormalities of Mineral Metabolism in Rats with Glycopeptide-Induced Nephritis", Endocrinology, 107, 1, 1980.
10.27.
Pamukcu, A.M. et al. "Effects of the Coadministration of Thiamine on the Incidence of Urinary Bladder Carcinomas in Rats Fed Bracken Fern", Cancer Research, 30:2671-2674, November 1970.
10.28.
Reddy, Bandaru et al. "Effect of Dietary Fish Oil on Azoxymethane-induced Colon Carcinogenesis in Male F344 Rats", Cancer Research, 46:3367-3370, July 1986.
10.29.
Renaud, S. et al. "Comparative Beneficial Effects on Platelet Functions and Atherosclerosis of Dietary Linoleic and -Linolenic Acids in the Rabbit", Atherosclerosis, 45:43-51, 1982.
10.30.
Riley, V. "Mouse Mammary Tumors: Alteration of Incidence as Apparent Function of Stress", Science, 189, August 8, 1975.
10.31.
Rothschild, Jonathan. "The Role of Carnitine in Medicine and Biological Systems", Journal of the IAPM, 8, 5, July 1984.
10.32.
Smith, Gilbert et al. "Chemical Carcinogenesis in C3H/StWi Mice, A Worthwhile Experimental Model for Breast Cancer", Cancer Research, 38:4504-4509, December 1978.
10.33.
Szczeklik, A. et al. "Dihomo--Linolenic Acid in Patients with Atherosclerosis: Effects on Platelet Aggregation, Plasma Lipids and Low-Density Lipoprotein-Induced Inhibition of Prostacyclin Generation", Thromb Hamost, 51, 2, April 30, 1984.
10.34.
Wainberg, M.A. et al. "Tumor Immunoprophylaxis and Immunotherapy in Guinea Pigs Treated with the Methanol Extraction Residue (MER) of BCG", 1976.


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