It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia All Documents and Media  
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Manuscript Notes and Typescripts

57 documents

Notes re: "On Cross Reactions of Immune Sera to Azoproteins." 1930s.
Notes by Linus Pauling on a publication by Karl Landsteiner and J. van der Scheer, which originally appeared in The...  View all information. 

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Notes re: "Immunochemistry." 1930s.
Notes by Linus Pauling on a publication by M. W. Chase and Karl Landsteiner, which originally appeared in Annual Review...  View all information. 

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"Hb and O2 equilibrium." February 20 - March 7, 1935.
View all information. 14 pages total.

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"Outline of Experiments on Hemochromagen." June 25, 1935.
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"The Structure of Proteins." 1936.
Published as "On the Structure of Native, Denatured, and Coagulated Proteins."  View all information. 13 pages total.

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"Hemoglobin and Magnetism." May 12, 1937.
Formal chapter installation of Sigma Xi, Oregon State College, Corvallis, Oregon.  View all information. 7 pages total.

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"Proteins." April 22 - May 17, 1938.
Research notebook containing early notes by Pauling on antibodies and antigens.  View all information. 5 pages total.

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"A Theory of the Structure and Process of Formation of Antibodies." July 27, 1940.
View all information. 33 pages total.

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"The Production of Antibodies in vitro." 1942.
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"Talk at Memorial Services for Elizabeth Swingle." September 27, 1943.
Pasadena, California. [?]  View all information. 

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"Reconsideration of the Hemoglobin-Oxyhemoglobin Equilibrium." November 16, 1944.
View all information. 7 pages total.

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"Blood Substitutes." February 16, 1945.
Speech delivered before the Los Angeles Academy of Medicine, California.  View all information. 

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"Molecular Structure and Biological Specificity." July 17, 1947.
View all information. 12 pages total.

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"The Electronic Structure of Hemoglobin." November 13, 1948.
View all information. 

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"The Condensation and Oxidation of Gelatin with Glyoxal and Hydrogen Peroxide for the Preparation of a Plasma Substitute (Oxypolygelatin)." 1949.
View all information. 6 pages total.

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"Difference in Electrophoretic Behavior of Sickle Cell Hemoglobin and Normal Human Hemoglobin." April 27, 1949.
Used in a talk advertised as "Sickle Cell Anemia, a Molecular Disease." National Academy of Sciences, Annual Meeting, Washington, D.C. [LP did not attend]  View all information. 

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Excerpts from Harvey Itano's doctoral dissertation. 1950.
Dissertation titled: "Part I: Contributions to the Study of Sickle Cell Hemoglobin; Part II: A Rapid Diagnostic Test for Sickle...  View all information. 49 pages total.

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"Sickle Cell Anemia, A Molecular Disease." 1950.
Letter to the Editor of Nature.  View all information. 8 pages total.

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"Molecular Disease." 1950s.
Notes prepared by Linus Pauling for an appearance on NBC television, December 13, year unknown. [1950s]  View all information. 

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Pauling note to self titled "Suggested Research." May 5, 1950.
Pauling notes research being conducted by Ludwing Anigstein on the digestive system of ticks. Based on Anigstein's findings, Pauling...  View all information. 

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"Memo to Linus Pauling from Himself." February 12, 1951.
Note to himself regarding the types of research he would like to do on hemoglobin. Pauling lists studies of...  View all information. 

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Notes re: "Abnormality of Hemoglobin Molecules in Hereditary Hemolytic Anemias." April 29, 1954.
Used by Pauling in the preparation of his Harvey Lecture, New York Academy of Medicine, New York City.  View all information. 

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"The Structure and Biological Properties of Molecules." November 1954.
Vanuxem Lectures, Princeton University, Princeton, New Jersey.  View all information. 

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"Recent Reports Related to the Contents of the Harvey Lecture." approx. 1955.
View all information. 9 pages total.

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"Nomination of Harvey A. Itano, M.D., Ph.D. for the Theobold Smith Award for 1955." July 1955.
View all information. 7 pages total.

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"Basic Biochemical Research Related to the Problem of Mental Deficiency." July 7, 1955.
Notes from a discussion at Pacific State Hospital, Los Angeles, California.  View all information. 15 pages total.

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"The Future of Enzyme Research." November 1, 1955.
Fourth Edsel B. Ford Lecture, Henry Ford Hospital, Detroit, Michigan.  View all information. 9 pages total.

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Annotated cover of "The Biological Effects of Atomic Radiation: Summary Reports." 1956.
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"The Molecular Basis of Genetics." May 2, 1956.
View all information. 10 pages total.

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"Abnormal Hemoglobin Molecules in Relation to Disease." 1957.
View all information. 16 pages total.

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"Factors Affecting the Structure of Hemoglobins and Other Proteins." June 20, 1957.
View all information. 10 pages total.

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"Molecular Structure and Disease." October 9, 1958.
Lowell Lecture, Massachusetts General Hospital, Boston, Massachusetts.  View all information. 10 pages total.

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"The Molecular Basis of Disease." March 29, 1959.
American Orthopsychiatric Association, San Francisco, California.  View all information. 6 pages total.

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Notes re: the development of immunity to malaria, 1960s.
Notes by Linus Pauling recording "the legendary story of the Tharus and the Bhuksas," as recounted by Ritchie Calder in...  View all information. 

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Notes re: a criticism of Pauling and Zuckerkandl's theory of evolution and molecular disease. 1960s.
Notes by Linus Pauling in response to C.H. Waddington's criticism of the Pauling/Zuckerkandl theory of evolution and molecular disease.  View all information. 

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"Biology - what are the likely developments?" 1960s.
Notes in which Pauling suggests that sex control, genetic repair, genetic control and chemical control are among the concepts likely...  View all information. 

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"Thalassæmia and the Abnormal Human Hæmoglobins." May 29, 1961.
View all information. 

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"The Genetic Effects of Radioactive Fallout and Carbon 14 Produced by Nuclear Weapons Tests." October 13, 1962.
Published as "Genetic Effects of Weapons Tests" in the Bulletin of the Atomic Scientists.  View all information. 10 pages total.

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"Molecular Disease and Evolution." November 5, 1962.
Rudolf Virchow Lecture, Columbia University, New York.  View all information. 

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"Scientific Factors Bearing on World Problems." December 14, 1962.
View all information. 6 pages total.

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"The Molecular Basis of Sickle-cell Anemia and Other Diseases." August 13, 1963.
Scientific Assembly of the National Medical Association, Los Angeles, California.  View all information. 

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"Molecular Disease and Evolution." September 16, 1963.
View all information. 9 pages total.

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"Nature of the Iron-Oxygen Bond in Oxyhaemoglobin." May 27, 1964.
View all information. 5 pages total.

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Manuscript re: Molecular Medicine and Anesthesia. November 23, 1964.
Eliasberg Memorial Lecture, New York.  View all information. 

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"Molecules as Documents of Evolutionary History." 1965.
View all information. 19 pages total.

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"Orthomolecular Methods in Medicine." May 12, 1967.
View all information. 13 pages total.

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"The Advancement of Knowledge - Orthomolecular Psychiatry." February 25, 1969.
Oregon State University Centennial Lecture, Corvallis, Oregon.  View all information. 25 pages total.

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"The Molecular Basis of Health and Disease." April 15, 1969.
All-College Centennial Lecture, Wilson College, Chambersburg, Pennsylvania.  View all information. 14 pages total.

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"Robert Brainard Corey." May 5, 1971.
Delivered at Corey's memorial meeting, California Institute of Technology, Pasadena.  View all information. 6 pages total.

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"Reminiscences" [re: the death of Arne Tiselius], November 4, 1971.
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"The Impact of Molecular Information on Disease." January 20, 1972.
Twentieth Annual Symposium on Blood, Wayne State University School of Medicine, Detroit, Michigan.  View all information. 

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"Chance In Evolution - Some Philosophical Remarks." June 1972.
View all information. 18 pages total.

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"The Genesis of the Concept of Molecular Disease." 1973.
View all information. 8 pages total.

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Pauling Note to Self re: sickle cell crisis incurred while under anesthesia. November 1975.
Pauling records the details of a phone conversation that he recently had with Dr. Hasson in which an incident of...  View all information. 

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"Ascorbic Acid and Cancer." February 14, 1976.
Presented at a meeting of the California Orthomolecular Society, San Francisco, California.  View all information. 14 pages total.

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"Orthomolecular Medicine." November 6, 1976.
Speech delivered to the Southern California Section, American Society for Microbiology, San Diego, California.  View all information. 

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"The Molecular Evolutionary Clock." March 30, 1992.
View all information. 

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