"Continental Classroom - A Course in Modern Chemistry" 1960. A production of the National Broadcasting Company and the Learning Resources Institute
in cooperation with the American Association of Colleges for Teacher Education and
the American Chemical Society.
A Model of Hemoglobin. (1:28)
Transcript
Linus Pauling: The problem then that we have had in recent years in attempting to understand the
structure of proteins is that of determining the nature of polypeptide chains in proteins.
I have a model here that I may use to represent the structure of the hemoglobin molecule.
It was discovered a few years ago that the hemoglobin molecule contains four polypeptide
chains each consisting of about one hundred fifty amino acid residues, and this model
represents one of these chains. The first unit may represent an amino acid such as
alanine or phenylalanine, it is in fact the amino acid valine. The second might be
another one - glycine, alanine, phenylalanine, or glutamic acid. It is, in one of
the chains, lucine and in another it is histadine. The third, the fourth, the fifth,
and so on. Chemists now know what the chemical nature of the first dozen amino acids
in the alpha-chain of hemoglobin and also in the beta-chain is.
