It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia Narrative  
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Pauling's work on hemoglobin and sickle cell anemia adds new insights and depth to Pauling's research and influence in chemistry, molecular biology, and medicine. Some general conclusions can be stated about Pauling's tactics for conducting laboratory research and gaining funding.

Foremost, Pauling did not accomplish his work alone, but in fact, he directed research and had the help of numerous collaborators over the years. Typically, Pauling made theoretical assumptions and then suggested experiments to someone in his laboratory, as was the case for sickle cell anemia. Other times he reversed the process; hence, he suggested experiments and used the data to develop a theory, as was the case for devising the alpha-helix.

Additionally, Pauling surrounded himself with people who helped him achieve his goals. In 1935 when he wanted to learn more about protein denaturation, he brought Alfred Mirsky of the Rockefeller Institute to Caltech for a couple of years. Similarly, Pauling enlisted Arthur Robinson's help to start the Linus Pauling Institute in the early 1970s.

Pauling's skill at writing scientific research grants helped him to gain sizeable funds from outside organizations. His success as a chemist at Caltech depended largely on the Rockefeller Foundation's investment in Caltech and in Pauling himself, which allowed for sufficiently more laboratory space, equipment, and researchers. Additionally, Pauling's vision for the future of Caltech and his fundraising efforts contributed to building Caltech into a premier scientific research institute.

Yet, Linus Pauling's status rests not only on his intellect and tactics, but also his optimism, curiosity, and enthusiasm for science and for life.

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Video Clip  Video: Supreme Faith in the Power of Science. 1976. (0:23) Transcript and More Information

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Linus Pauling delivering his Richards Medal address. May 9, 1947.

Harvey Itano and Linus Pauling. 1980s.

"Science cannot be stopped. Man will gather knowledge no matter what the consequences -- and we cannot predict what they will be. Science will go on -- whether we are pessimistic, or are optimistic, as I am. I know that great, interesting, and valuable discoveries can be made and will be made...But I know also that still more interesting discoveries will be made that I have not the imagination to describe -- and I am awaiting them, full of curiosity and enthusiasm."

Linus Pauling
October 15, 1947
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