It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia Narrative  
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Chemical Biology
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In the first couple of years after Pauling became interested in molecular medicine he hoped to make people healthier with artificial enzymes. He thought diseases could be combated by making enzymes that inhibit or induce chemical reactions that occur inside the human body. Pauling aimed to learn more about chemical structures of proteins, enzymes, and other bodily compounds in an effort to gain an understanding of the basics of diseases, as opposed to attacking each affliction individually and haphazardly.

To aid him, Pauling teamed up with three men for a collaborative research project on mental illnesses, which was conducted largely at Caltech. Two of the men, Dr. George Tarjan of Pacific State Hospital and Dr. Stanley Wright of UCLA Medical School, worked with mentally disabled people. The other man was Richard Morgan, a member of the California Office of the Department of Mental Hygiene. The four men discussed possible areas of research in 1955 and decided that Pauling should submit a grant proposal to the Ford Foundation, a philanthropic foundation that aimed "to receive and administer funds for scientific, educational, and charitable purposes, all for the public welfare." The four men received generous grants; the Ford Foundation gave Caltech $450,000 over five years and UCLA $500,000.

In 1955 Caltech finished building the Norman W. Church Laboratory of Chemical Biology, the location for most of the new research. In addition to money from the Ford Foundation, Caltech also received from the Rockefeller Foundation $700,000 to help build the Church Laboratory, and an additional $800,000 for the research conducted in it.

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Audio Clip  Audio: Revolutionary Possibilities in the Treatment of Disease. 1967. (1:01) Transcript and More Information

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Video Clip  Video: The Future of Enzyme Research and Treatments. 1960. (1:23) Transcript and More Information

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See Also: "Caltech Gets $450,000 for Mental Study" August 1956. 
See Also: Letter from Linus Pauling to Robert Corey. August 24, 1960. 

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Picture
Architectural rendering of the Norwan W. Church Laboratory of Chemical Biology, California Institute of Technology. approx. 1955.


Typescript - Page 1
"The Future of Enzyme Research." November 1, 1955.

"As to the Chemical-Biology building, we hope very much that Mr. Norman Church will make provisions so that we can start work on it in the near future. As Kirkwood has no doubt told you, Mr. Church has pledged himself to provide $1,500,000 for a Chemical-Biology building....It was the greatest good fortune, indeed, that he offered this gift just at the time when the Rockefeller gift came through."

Lee DuBridge
May 24, 1948
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