It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia Other Information  
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Bibliography of Scientific Resources

A compilation of scientific publications germane to the subjects discussed on this website.


Beutler, Ernest. "The Effect of In Vivo Modification of Sickle Cell Disease." Clinical Research. 1960, 8: 101.

Bush, Vannevar. Office of Scientific Research and Development. Science: The Endless Frontier. Washington, D.C.: United States Printing Office, 1945.

Daland, Geneva A. and William B. Castle, "A Simple and Rapid Method for Demonstrating Sickling of the Red Blood Cells: The Use of Reducing Agents." Journal of Laboratory and Clinical Medicine 1948, 33: 1082-088.

Goldstein, Mervyn L. "High Dose Ascorbic Acid Therapy." Journal of the American Medical Association. 1972, 216: 332.

Gray, George W. "Sickle Cell Anemia." Scientific American. August 1951, 185(2): 56-59.

---. "Electrophoresis." Scientific American. December 1951, 185(6): 45-53.

Havinga, Egbert and Harvey A. Itano. "Electrophoretic Studies of Globins Prepared from Normal Adult and Sickle Cell Hemoglobins." Proceedings of the National Academy of Sciences of the United States of America. 1953, 39: 65-67.

Ingram, Vernon. "A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anaemia Haemoglobin." Nature, 1956, 178: 792-94.

---. "Gene Mutations in Human Haemoglobin: The Chemical Difference between Normal and Sickle Cell Haemobglobins." Nature. 1957, 180: 326-28.

Itano, Harvey A. "A Third Abnormal Hemoglobin Associated with Hereditary Hemolytic Anemia." Proceedings of the National Academy of Sciences. 1951, 37: 775-84.

---. "Human Hemoglobin." Science. 1953, 117: 89-94.

---. "Clinical States Associated with Alterations of the Hemoglobin Molecule." Archives of Internal Medicine. 1955, 96: 287-97.

Itano, Harvey, William Bergren, and Phillip Sturgeon. "Identification of a Fourth Abnormal Human Hemoglobin." Journal of the American Chemical Society. 1954, 76: 2278.

---. "The Abnormal Human Hemoglobins." Medicine. 1956, 35: 121-59.

Itano, Harvey A. and James V. Neel. "A New Inherited Abnormality of Human Hemoglobin." Proceedings of the National Academy of Sciences of the United States of America. 1950, 36: 613-17.

Itano, Harvey A. and Linus Pauling. "Abnormal Hemoglobin Molecules in Relation to Disease." Svensk Kemisk Tidskrift. 1957, 69: 509-23.

---. "A Rapid Diagnostic Test for Sickle Cell Anemia" Blood. January 1949 4(1): 66-68.

Itano, Harvey A. and Elizabeth A. Robinson. "Genetic Control of the α- and β-Chains of Hemoglobin." Proceedings of the National Academy of Sciences of the United States of America 1960, 11: 1492-501.

Itano, Harvey A. and S. J. Singer, "On Dissociation and Recombination of Human Adult Hemoglobins A, S, and C." Proceedings of the National Academy of Sciences of the United States of America. 1958, 44: 522-29.

Landsteiner, Karl. The Specificity of Serological Reactions. Baltimore, Maryland: C.C. Thomas, 1936.

Landsteiner, Karl and C. Phillip Miller, Jr. "Serological Studies on the Blood of the Primates. I. The Differentiation of Human and Anthropoid Bloods." Journal of Experimental Medicine. 1925, 42: 841-52.

---. "Serological Studies on the Blood of the Primates. II. The Blood Groups in Anthropoid Apes." Journal of Experimental Medicine. 1925, 42: 853-62.

---. Serological Studies on the Blood of the Primates. III. Distribution of Serological Factors Related to Human Isoagglutinogens in the Blood of Lower Monkeys." Journal of Experimental Medicine. 1925, 42: 863-72.

Medawar, Peter. "The Genetic Improvement of Man." The Hope of Progress. London: Methuen and Company, Ltd., 1972. 69-76.

Mirsky, Alfred E. and Linus Pauling. "On the Structure of Native, Denatured, and Coagulated Proteins." Proceedings of the National Academy of Sciences of the United States of America. 15 July 1936, 22: 439-47.

Murayama, Makio and Robert Nalbandian. Sickle Cell Hemoglobin: Molecule to Man. Boston: Little, Brown and Company, 1973.

Neel, James V. "The Inheritance of Sickle Cell Anemia." Science. 1949, 110: 64-66.

---. "The Inheritance of the Sickling Phenomenon, with Particular Reference to Sickle Cell Disease." Blood. 1951, 6: 389-412.

Neel, James V., Ibert C. Wells and Harvey A. Itano. "Familial Differences in the Proportion of Abnormal Hemoglobin present in Sickle Cell Trait." Journal of Clinical Investigation. 1951, 30: 1120-124.

Pauling, Linus. "The Nature of the Chemical Bond. Application of Results Obtained from the Quantum Mechanics and from a Theory of Paramagnetic Susceptibility to the Structure of Molecules." Journal of the American Chemical Society. April 1931, 53: 1367-1400.

---. "The Oxidation Equilibrium of Hemoglobin and its Structural Interpretation." Proceedings of the National Academy of Science of the United States of America. 15 April 1935, 21: 186-91.

----. The Nature of the Chemical Bond and the Structure of Molecules and Crystals: An Introduction to Modern Structural Chemistry. New York: Cornell University Press, 1939.

---. "A Theory of the Structure and Process of Formation of Antibodies." Journal of the American Chemical Society. 1940, 62: 2643-657.

---. "Molecular Structure and Intermolecular Forces." The Specificity of Serological Reactions. Ed. Karl Landsteiner. Cambridge, Massachusetts: Harvard University Press, 1945. 275-97.

---. "Analogies between Antibodies and Simpler Chemical Substances." Chemical and Engineering News, 1946, 24: 1064-065.

---. "The Interpretation of Some Chemical Properties of Hemoglobin in Terms of its Molecular Structure." Stanford Medical Bulletin. February 1948, 6(1): 215-22.

---. "The Electronic Structure of Haemoglobin." Haemoglobin. Symposium based on a Conference held at Cambridge in June 1948 in memory of Sir Joseph Barcroft. Eds. F. J. W. Roughton and J. C. Kendrew. London: Butterworths Scientific Publications, 1949. 57-65.

---. "The Hemoglobin Molecule in Health and Disease." Proceedings of the American Philosophical Society. 1952, 96: 556-65.

---. "Abnormality of Hemoglobin Molecules in Hereditary Hemolytic Anemias." The Harvey Lectures 1953-4. 1955, 49: 216-41.

---. "The Future of Enzyme Research." Enzymes: Units of Biological Structure and Function. Ed. Oliver H. Gaeblers. New York: Academic Press, Inc., 1956. 177-82.

---. "The Molecular Basis of Genetics." American Journal of Psychiatry. 1956, 113: 492-95.

---. "Current Opinion: Molecular Disease." Pfizer Spectrum. 1 May 1958, 6(9): 234-35.

---. No More War! Connecticut: Greenwood Press, Publishers, 1958.

---. "Molecular Disease." American Journal of Orthopsychiatry. 1959, 29(4): 684-87.

---. "Molecular Structure in Relation to Biology and Medicine." Ciba Foundation Tenth Anniversary Symposium on Significant Trends in Medical Research. Eds. G.E.W. Wolstenholme, Cecilia M. O'Connor, Maeve O'Connor. Boston, Massachusetts: Little, Brown, and Company, 1959. 3-10.

---. "Molecular Structure and Disease." Disease and the Advancement of Basic Science. Ed. Henry K. Beecher. Cambridge, Massachusetts: Harvard University Press, 1960. 1-7.

---. "Early work on X-ray diffraction in the California Institute of Technology." Fifty Years of X-ray diffraction. Ed. P.P Ewald. Utrecht: International Union of Crystallography, 1962. 623-28.

---. "The Molecular Basis of Genetic Defects." Congenital Defects. Philadelphia: J.B. Lippincott, 1963. 15-21.

---. "Our Hope for the Future." Birth Defects. Ed. Morris Fishbein. Philadelphia: J.B. Lippincott Company, 1963. 164-70.

---. "Molecular Disease and Evolution." Rudolf Virchow Medical Society Lecture. Proceedings of the Rudolf Virchow Medical Society of New York. 1963, 21: 131-40.

---. "The Nature of the Iron-Oxygen Bond in Oxyhaemoglobin." Nature. 1964, 203: 182-83.

---. "Science and World Problems." Enzymes in Mental Health. Eds. Gustav J. Martin and Bruno Kisch. Philadelphia: JB Lippincott Company, 1966. 13-18.

---. "Orthomolecular Psychiatry." Science. 19 April 1968, 160: 265-71.

---. "Reflections on the New Biology: Foreword." UCLA Law Review. 1968, 15(2): 267-72.

---. "Medicine in a Rational Society." Journal of the Mount Sinai Hospital of New York. 1969, 36: 194-99.

---. "Fifty Years of Progress in Structures of Chemical and Molecular Biology" Daedalus. 1970, 99(4): 988-1015.

---. Vitamin C and the Common Cold. San Francisco: W. H. Freeman and Company, 1970.

---. Foreword. Molecular Aspects of Sickle Cell Hemoglobin: Clinical Applications. Ed. Robert M. Nalbandian. Springfield, Illinois: Charles C. Thomas Publisher, 1971. vii-x.

---. "Magnetic Properties and Structures of Oxyhemoglobin." Proceedings of the National Academy of Sciences of the United States of America. 1972, 74: 2612-613.

---. "The Genesis of the Concept of Molecular Disease." Sickle Cell Disease. Eds. E.F. Mammen, G.F. Anderson, and M.I. Barnhart. Stuttgart and New York: F.K. Schattauer Verlag, 1973. 1-6.

---. "The Normal Hemoglobins and the Hemoglobinopathies: Background" Hemoglobins and Hemoglobinopathies: A Current Review to 1981. Texas Reports on Biology and Medicine. 1980-1981, 40: 1-7.

---. "Early Days of Molecular Biology in the California Institute of Technology." Annual Review of Biophysics and Biophysical Chemistry. 1986, 15: 1-9.

---. How to Live Longer and Feel Better. New York: W. H. Freeman and Company, 1986.

---. Foreword. Sickle Cell Disease: Basic Principles and Clinical Practice. Eds. Stephen H. Embury, R. P. Hebbel, N. Mohandas, and M. H. Steinberg. New York: Raven Press, 1994. xvii-xix.

---. Foreword. Membrane Abnormalities in Sickle Cell Disease and in other Red Blood Cell Disorders. Eds. Ohnishi, S. Tsuyoshi and Tomoko Ohnishi. Boca Raton, Florida: CRC Press, 1994. viii-ix.

Pauling, Linus and Dan H. Campbell. "The Production of Antibodies in Vitro." Science. 1942, 95: 440-41.

Pauling, Linus, Dan H. Campbell, and David Pressman. "The Nature of the Forces between Antigen and Antibody and of the Precipitation Reaction." Physiological Reviews. 1943 23(3): 203-19.

---. "Serological Reactions with Simple Substances Containing Two or More Haptenic Groups," Proceedings of the National Academy of Sciences of the United States of America 27 (15 Feb 1941): 125-28.

Pauling, Linus and Robert B. Corey. "The Polypeptide-Chain Configuration in Hemoglobin and other Globular Proteins." Proceedings of the National Academy of Sciences of the United States of America. 1951, 37(5): 282-85.

Pauling, Linus, Robert B. Corey, and H. R. Branson. "The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain." Proceedings of the National Academy of Sciences of the United States of America. 1951, 37: 205-11.

Pauling, Linus and Charles D. Coryell. "The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin." Proceedings of the National Academy of Sciences of the United States of America. 1936, 22: 210-16.

Pauling, Linus and Roger Hayward. The Architecture of Molecules. San Francisco and London: W.H. Freeman and Company, 1964.

Pauling, Linus, Harvey A. Itano, S. J. Singer, Ibert C. Wells. "Sickle Cell Anemia, a Molecular Disease." Science. 1949, 110: 543-48.

Reprinted as: ---. "Sickle Cell Anemia, a Molecular Disease." Papers on Human Genetics. Ed. Samuel H. Boyer IV. New Jersey: Prentice-Hall, Inc., 1963. 115-25.

Pauling, Linus and J. Sherman. "The Nature of the Chemical Bond. VI. The Calculation from Thermochemical Data of the Energy of Resonance of Molecules among Several Electronic Structures." Journal of Chemical Physics. August 1933, 1: 606-17.

---. "The Nature of the Chemical Bond. VII. The Calculation of Resonance Energy in Conjugated Systems." Journal of Chemical Physics. October 1933, 1: 679-86.

Pauling, Linus and G.W. Wheland. "The Nature of the Chemical Bond. V. The Quantum-Mechanical Calculation of the Resonance Energy of Benzene and Naphthalene and the Hydrocarbon Free Radicals." Journal of Chemical Physics. June 1933, 1: 362-74.

Pauling, Linus and Emile Zuckerkandl. "Chemical Paleogenetics: Molecular 'Restoration Studies' of Extinct Forms of Life." Acta Chemica Scandinavica. 1963, 17: 9-16.

Pressman, David, Dan H. Campbell and Linus Pauling. "Complement Fixation with Simple Substances Containing Two or More Haptenic Groups" Proceedings of the National Academy of Sciences of the United States of America. 1941, 28(3): 77-79.

Rhinesmith, Herbert S., W. A. Schroeder and Linus Pauling. "A Quantitative Study of the Hydrolysis of Human Dintirophenyl (DNP) Globin: The Numbers and Kind of Polypeptide Chains in Normal Adult Human Hemoglobin." Journal of the American Chemical Society. 1957, 79: 4682-86.

Rhinesmith, Herbert S. W. A. Schroeder and Linus Pauling. "The N-Terminal Amino Acid Residues of Normal Adult Hemoglobin: A Quantitative Study of Certain Aspects of Sanger's DNP-Method." Journal of the American Chemical Society. 1957, 79: 609-15.

Schroeder, W. A., Lois M. Kay, Ibert C. Wells. "Amino Acid Composition of Hemoglobins of Normal Negroes and Sickle-Cell Anemics." Journal of Biological Chemistry. 1950, 187: 221-40.

Singer, S. J. and Harvey A. Itano. "On the Asymmetrical Dissociation of Human Hemoglobin." Proceedings of the National Academy of Sciences of the United States of America. 1959, 45: 174-84.

St. George, Robert C.C. and Linus Pauling. "The Combining Power of Hemoglobin for Alkyl Isocyanides, and the Nature of the Heme-Heme Interactions of Hemoglobin." Science. 1951, 114: 629-34.

Swingle, Stanley M. "An Electrophoresis Apparatus Using Parabolic Mirrors" Review of Scientific Instruments. 1947 18(2): 128-32.

Wells, Ibert C. and Harvey Itano. "Ratio of Sickle Cell Anemia Hemoglobin to Normal Hemoglobin in Sicklemics." Journal of Biological Chemistry. 1951, 188: 65-74.

Wright, George G. and Stanley M. Swingle. "The Construction of Tiselius Electrophoresis Cells." Science. 1943, 97: 564.

Zuckerkandl, Emile, Richard T. Jones, and Linus Pauling. "A Comparison of Animal Hemoglobins by Tryptic Peptide Pattern Analysis." Proceedings of the National Academy of Science of the United States of America. 15 October 1960, 46: 1349-360.

Zuckerkandl, Emile and Linus Pauling. "Molecular Disease, Evolution, and Genic Heterogeneity." Horizons in Biochemistry. Eds. Michael Kasha and Bernard Pullman. New York: Academic Press, 1962. 189-225.

---. "Evolutionary Divergence and Convergence in Proteins." Evolving Genes and Proteins: A Symposium. Eds. Vernon Bryson and Henry J. Vogel. New York Academic Press, 1965. 97-166.

---. "Molecules as Documents of Evolutionary History." Journal of Theoretical Biology. 1965, 8: 357-66.

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