"I think it has really been very much worthwhile for me to get away for this period
of time, under circumstances favorable to my thinking over questions and trying to
find their solution." Linus Pauling. Letter to Robert Corey. March 3, 1948.
"He and I together decided that he should work on the determination of the structure
of some crystals of amino acids and simple peptides. When I say that he and I together
made this decision, I may not be quite right. It is not unlikely that he had already
made the decision, and that he arranged to have me agree with him, in such a way that
I would think that we had made the decision together. I learned later that he was
very good at this..." Linus Pauling. "Robert Brainard Corey." May 3, 1971.
"On my return to Pasadena in the fall of 1948 I talked with Professor Corey about
the alpha helix and the gamma helix, and also with Dr. Herman Branson, who had come
for a year as a visiting professor. I asked Dr. Branson to go over my calculations,
and in particular to see if he could find any third helical structure. He reported
that the calculations were all right, and that he could not find a third structure." Linus Pauling. "The Discovery of the Alpha Helix." September 1982.
"...[T]hree ways of folding polypeptide chains have turned out to constitute the most
important secondary structures of all proteins. Dr. Corey, to some extent with my
inspiration, designed molecular models of several different kinds that were of much
use in the later effort to study other methods of folding polypeptide chains. I used
these units to make about 100 different possible structures for folding polypeptide
chains." Linus Pauling. "The Discovery of the Alpha Helix." September 1982.
"[Corey and I] reached the conclusion, as did Crick, that in the alpha-keratin proteins
the alpha helices are twisted together into ropes or cables. This idea essentially
completed our understanding of the alpha-keratin diffraction patterns." Linus Pauling. "The Discovery of the Alpha Helix." September 1982.
"During a single year, using his own x-ray equipment, Corey made great strides into
the protein puzzle. He showed that in the crystalline dipeptide diketopiperazine
(a simplified analogue of amino acids), the amide bonds were coplaner, strongly suggesting
the presence of a resonance structure - observations that fit precisely with Pauling's
studies of the amide bond in urea during the early 1930s." Lily E. Kay. The Molecular Vision of Life: Caltech, The Rockefeller Foundation and the Rise of
the New Biology (New York: Oxford University Press). 1993.
"While my own work at Caltech had nothing to do with protein structure, Pauling used
to talk to me occasionally about his models and what one could learn from them. In
his lecture, he had talked about spirals. In conversation a few days later, I told
him that for me the word "spiral" referred to a curve in a plane. As his polypeptide
coils were three-dimensional figures, I suggested they were better described as "helices."
Pauling's erudition did not stop at the natural sciences. He answered, quite correctly,
that the words "spiral" and "helix" are practically synonymous and can be used almost
interchangeably, but he thanked me for my suggestion because he preferred "helix"
and declared that he would always use it henceforth. Perhaps he felt that by calling
his structure a helix there would be less risk of confusion with the various other
models that had been proposed earlier. In their 1950 short preliminary communication,
Pauling and Corey wrote exclusively about spirals, but in the series of papers published
the following year the spiral had already given way to the helix. There was no going
back. A few years later we had the DNA double helix, not the DNA double spiral. The
formulation of the α-helix was the first and is still one of the greatest triumphs
of speculative model building in molecular biology, and I am pleased that I helped
to give it its name." Jack Dunitz. "La Primavera." (unpublished manuscript) 2011.
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