Balliol College
Oxford, England
April 1, 1948
Dr. Carl G. Niemann
Crellin Laboratory
California Institute of Technology
Pasadena 4, California
Dear Carl:
You have my approval of offering postdoctorate appointments at $3500 a year for the
year 1948-9 to the two men mentioned in your letter, the Chinese and the Swiss. I
think that it would be wise to plan to have them work on means of preventing the destruction
of insulin in vivo by use of inhibitors for the enzymes that destroy insulin or by modifying the insulin
molecule. The possibility of a change in this plan can be discussed later.
I must say that the results that Chibnall reported on the nature of the end-groups
in insulin and of the sequence of the first half dozen amino acids in one of the polypeptide
chains looked very good to me. The technique of marking one of the ends by a colored
group and then isolating degradation products by paper chromatography seems to be
working out excellently.
I am looking forward to getting home again, and to seeing you in the fall.
Sincerely yours,
Linus Pauling:par
cc: R. B. Corey
