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Interview with William Lipscomb.
 
Interview with William Lipscomb. November 3, 1991.
Interview by Thomas Hager for use in "Force of Nature: The Life of Linus Pauling," (Simon & Schuster, 1995).

A Marvelous Haptenes Project (1:18)

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William Lipscomb: He said, "Bill, why don’t you take some samples, prepare some samples of antigen antibody and take them up to the electron microscope and see what you can find. See if you can find the structure of the antibody in this complex, of the haptens." Marvelous project. I don’t remember who did it, I think it was Valentine [?] who actually did the experiment, and found the three fold symmetric of three antibodies tied together with haptenes, which are T-shaped, you know. Bound together, the haptenes make a three-fold symmetric thing. I missed it! Because my preparations weren't very good. It is a project which requires much more time, much more careful work than I understood at the time. But it triggered my interest in biochemistry right along with all the antibody work that Dan Campbell was doing at Linus's suggestion.

That came from Landsteiner by the way, the haptene work. But Landsteiner didn’t make it quantitative, and Linus made lots of chemical variations, and free energy calculations of the binding site, he got some idea of the size of the binding site, all kinds of things that were right, along with the wrong idea that it folds.

Clip

Creator: Thomas Hager, William Lipscomb
Associated: Linus Pauling, Dan Campbell, Karl Landsteiner
Clip ID: hager2.002.6-haptens

Full Work

Creator: Thomas Hager, William Lipscomb

Date: November 3, 1991
Genre: sound
ID: hager2.002.6
Copyright: More Information

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