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Correspondence

Letter from Linus Pauling to A. N. Richards. May 1, 1944.
Pauling writes to request that the Committee on Medical Research grant to him and Dan Campbell a small contract to investigate the application of new experimental methods in the manipulation of penicillin.

Transcript

May 1, 1944

Dr. A.N. Richards

Committee on Medical Research

2101 Constitution Avenue

Washington, D.C.

Dear Dr. Richards:

This letter is in answer to yours of April 12th relating to our proposal for treatment of penicillin in such a way as to increase its retention in the blood stream.

We have recently obtained some very interesting experimental results on the formation of complexes of substances with serum protein, and Professor Campbell and I believe that it would be well worth while to try out these new methods, which do not depend upon knowledge of the chemical structure, on penicillin and possibly other physiologically active substances, without waiting for the release of information about the chemical structure of penicillin. I would like accordingly to make application for a small contract, permitting one or two men to work on this problem during the coming six months in case that your Committee considers the project promising. Would you please have a set of application blanks sent to me for this purpose?

If, later on, information about the chemical structure of penicillin were to be released to us, we could also try out the chemical methods of coupling which seem appropriate.

Sincerely yours,

Linus Pauling

LP:mu

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