May 6, 1952
Dr. John F. Tinker
Department of Chemistry
12 Oxford Street
Cambridge 38, Massachusetts
Dear Dr. Tinker:
I thank you for sending me a copy of your letter to Mr. Ronwin, about his paper on
the structure of nucleic acid and the note that Professor Schomaker and I have published
on the subject.
First, let me say that it is not a "detail" that we found defective in Ronwin's proposal.
The element of novelty in his structure is the five oxygen atoms around a phosphorus
atom. We mentioned that there is very strong evidence that structures of this sort
are not stable. This is a fundamental criticism rather than criticism of a detail.
Our criticism might have been much more extensive. For example, it is possible to
show by consideration of bond energies that the proposed structure is seriously unstable.
We refrained from including this consideration, and others bearing on the question,
because we thought our note might as well be as short as possible, compatible with
our goal - which was to prevent biochemists from wasting time and effort on a proposal
not deserving of this time and effort.
In this connection I may mention that Ronwin has found in the literature a description
of the synthesis of four substances that seen to involve five oxygen atoms about a
phosphorus a atom - an example is penta-phenolorthophosphate, P(OC6H5)5. These substances are extremely unstable, being decomposed rapidly by moisture.
This property of extreme instability in the presence of moisture is, of course, just
the property that would make Romwin's proposed structure for the nucleic acids inacceptable,
unless, as we stated in our note, there is an overwhelming necessity for the proposal
- such necessity as to require one to assume a great difference in stability from
Professor Schomaker and I, like other workers in the field of molecular structure,
know how easy it is to postulate hypothetical structures for substances. It is so
easy to do this that no reputable worker in
Dr. Tinker -2- 5/6/52
the field of molecular structure publishes descriptions of hypothetical structures
unless he has significant evidence in support of the structures. There is no strong
evidence in favor of Ronwin's hypothetical structure, as compared with other hypothetical
structures such as the one you mention in your letter.
I do not think that you are right in saying that Professor Schomaker and I criticize
novelty. What we are criticizing is foolish-ness - the irresponsible publication
of unsupported hypotheses. I may mention to you that some months ago I talked for
several hours with Mr. Ronwin about some other ideas of his about molecular structure,
and found that he has little knowledge of the precise information that has been gathered
about the structure of molecules during the last twenty-five years.
In the fourth paragraph of your letter you say that perhaps I am annoyed at my own
error, on page 109 of The Nature of the Chemical Bond. There is no error on this
page of The Nature of the Chemical Bond. The structures of the compounds of phospherous
described on this page are correct.