It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia All Documents and Media  
Home | Search | Narrative | Linus Pauling Day-By-Day

Key Participants


George W. Beadle
George E. Burch
Dan H. Campbell
William B. Castle
Robert B. Corey
Charles D. Coryell
Lee A. DuBridge
Vernon M. Ingram
Harvey A. Itano
Karl Landsteiner
Alfred E. Mirsky
Robert M. Nalbandian
James V. Neel
A. A. Noyes
Ava Helen Pauling
Linus Pauling
Walter A. Schroeder
S. Jonathan Singer
Stanley M. Swingle
Arne Tiselius
Warren Weaver
Ibert C. Wells
Paul L. Wolf
Emile Zuckerkandl

View all Key Participants

Portrait of Vernon M. Ingram
Portrait of Vernon M. Ingram, approx. 2004.
More Info

Vernon M. Ingram

1924-2006

Vernon M. Ingram Papers (in process)
Location: Massachusetts Institute of Technology Archives and Special Collections
Address: Building 14N-118, 77 Massachusetts Ave, Cambridge, Massachusetts 02139-4307
Phone: 617-253-5136  Fax: 617-258-7305
Email: mithistory@mit.edu  Web: http://libraries.mit.edu/archives/index.html

 

Correspondence

Pictures and Illustrations

Published Papers and Official Documents

Manuscript Notes and Typescripts

Quotes

"In 1949, application of methods of physical chemistry directly to the study of a protein produced by a mutated gene led Pauling, Itano, Singer and Wells to identify the specific change in the protein brought about by the gene. The discovery of the first of the abnormal human hemoglobins which they described as causing a 'molecular disease' -- sickle cell anemia -- was followed the identification of a large number of other proteins, each of which owed its difference from normal structure to a mutated gene. Ingram then showed that the change due to the mutation, in the case of each of two abnormal hemoglobins, was confined to a single amino acid residue at one point in one of the polypeptide chains composing the globin. There could be no doubt that genes controlled protein structure by specifying the sequence of amino acid residues in the polypeptide chains. The assumed basic functional correspondence was then altered from 'one gene-one enzyme' to 'one gene-one polypeptide.'"

L. C. Dunn. "Old and New in Genetics." Bulletin of the New York Academy of Medicine, 40(5): 325-333, 329. May 1964.

Audio Clips

Video Clips

Home | Search | Narrative | Linus Pauling Day-By-Day