California Institute of Technology Inter-Office Memo
To L. Pauling From A.C. Allison, M. Murayama, J. Vinograd Date Sept 9. 1954
Subject Summary of Investigation on the Properties of S Hb solutions carried out
at the Calif. Inst. Of Technology during August 1954.
Appended are summaries of research initiated during the visit of Dr. Allison. The
work deals with the phenomena which occurs when concentrated solutions of S Hb are
Since no part of the work is completed as yet tentative plans have been made to continue
the work along the following lines:
1. Berreman and Murayama will continue to examine by x-ray diffraction methods the
sickling of RBC, the formation of gels in deoxygenated S Hb, and possibility of fiber
formation by S Hb.
2. Dr. Allison will continue the examination of effect of temperature and hydrogen
bonding agents on gelation. It is anticipated that this work will be published in
a short time since it is now well advanced.
3. Demonstration of the applicability of the phase rule to the system during gel formation
will be carried out at C.I.T.