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Page 2 Letter from William Castle to Linus Pauling. November 29, 1946.(Large Version) Castle writes to thank Pauling for his letter and to discuss sickle cell research in greater depth. In so doing, Castle notes that the literature is full of publications indicating that oxygen and carbon monoxide prevent blood sickling, and provides greater details about his own work in determining the oxygen tension necessary to initiate sickling. Castle closes by indicating that his future research interests include measuring sickling as a function of blood viscosity. Date: November 29, 1946
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