It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia All Documents and Media  
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Hitchcock Foundation Lectures: "Chemical Bonds in Biology"
 
Hitchcock Foundation Lectures: "Chemical Bonds in Biology" January 17, 1983.
University of California, Berkeley.

Landsteiner's Groundbreaking Methods. (1:47)

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Linus Pauling: So, in 1936 I gave a Ground Rounds talk at the Rockefeller Institute for Medical Research, in New York, about hemoglobin. And after my talk, Karl Landsteiner asked if I would come to his laboratory and talk with him. He was doing very interesting work. He had discovered the blood groups back in 1900, A-B both.

And he was then making studies of the reactions of antibodies and the antigens -- homologous antigens or heterologous antigens. And in fact it was the sort of work that would appeal to a chemist because he would take a chemical off the shelf -- something with known structure, a simple substance -- and couple it to a protein, usually by diacetation of the amino group, and inject this azoprotein into a rabbit and get antibodies which were characteristic of this simple chemical. He would get a solution of protein molecules that would combine specifically with the chemical that he had took off the shelf -- something that no rabbit had ever seen before.

This was surely interesting to me, another example of biological specificity. These immune reactions are about as specific as you can get. You can detect the difference between, say, hen egg ovalbumin and duck egg ovalbumin when, up until recently, there were no other ways of showing that these two closely-related proteins were in fact different from one another.

Clip

Creator: Linus Pauling
Associated: Karl Landsteiner
Clip ID: 1983v.1-landsteiner

Full Work

Creator: Linus Pauling
Associated: University of California, Berkeley

Date: January 17, 1983
Genre: sound
ID: 1983v.1
Copyright: More Information

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